A new study on Saturday said that the second COVID wave in India was somewhat different than the first one, with higher mortality being reported in all age groups except those below 20 years, and more people developing acute shortness of breath and requiring supplemental oxygen and mechanical ventilation.
The study – Clinical profile of hospitalized COVID-19 patients in first and second wave of the pandemic: Insights from an Indian registry based observational study – was published in the Indian Journal of Medical Research and has been done by experts from the Indian Council of Medical Research (ICMR), All India Institute of Medical Sciences and National Centre for Disease Control (NCDC).
Since March after a period of decline from September last year India has witnessed a massive second surge of coronavirus cases. The study found that data collected under the National Clinical Registry for COVID-19 (NCRC) were examined to define the differences in demographic and clinical features of COVID-19 patients recruited during these two successive waves.
It mentioned that demographic, clinical, treatment and outcome data of hospitalized and confirmed COVID-19 patients were captured in an electronic data portal from 41 hospitals across India. The NCRC, launched in September last year, is an ongoing multi-centre observational initiative, which provided the platform for the current investigation.
The mean age of the patients was significantly lower in the second wave with higher proportion of patients in the younger age group intervals of less than 20 years, and 20-39 years, the study said. It said approximately 70 per cent of the admitted patients were above 40 years in both the waves of the pandemic and the proportion of males were slightly lower in second wave as compared to the first. As on May 11 this year, 18,961 individuals were recruited in the registry, 12,059 and 6,903 reflecting in-patients from the first and second waves respectively, it noted.
As on May 11 this year, 18,961 individuals were recruited in the registry, 12,059 and 6,903 reflecting in-patients from the first and second waves respectively, it noted. It said, patients enrolled between September 1, 2020 and January 31, 2021 and February 1 to May 11, 2021 constituted the participants of the two successive waves respectively.
The most common symptom was fever in both the waves, it said.
“In the second wave, a significantly higher proportion complained of shortness of breath, developed acute respiratory distress syndrome (ARDS), required supplemental oxygen and mechanical ventilation. “Mortality also was significantly increased in the second wave in all age groups except in below 20 years,” it said.
“The second wave of COVID-19 in India was slightly different in presentation than the first wave, with a younger demography, lesser comorbidities, and presentation with breathlessness in greater frequency,” the study stated.
Knowing that there are some limitations in the current investigation and it said that the registry did not capture the initial phase of the first wave as data collection commenced from September 1, 2020.
In obtaining a complete dataset there has been considerable delay due to the time required for data verification and the extraordinary workload of the healthcare team involved in COVID-19 care. Hence, the study further said that the outcome data were not available for many cases from the second wave.