IIT Mandi Researchers Unveil Potential Oral Treatment for Diabetes

IIT Mandi Researchers Unveil Potential Oral Treatment for Diabetes

Novel Drug Molecule ‘PK2’ Triggers Insulin Release in Diabetes Management

In a groundbreaking advancement, researchers at the Indian Institute of Technology Mandi have unveiled a potential breakthrough in diabetes treatment – an oral medication with the potential to stimulate insulin release. The remarkable drug molecule, named PK2, offers a promising avenue for individuals grappling with both Type 1 and Type 2 diabetes.

Publication in Journal of Biological Chemistry Highlights Promising Findings

The findings of this pioneering research have been published in the esteemed Journal of Biological Chemistry. Spearheaded by Dr. Prosenjit Mondal and co-authored by Prof. Subrata Ghosh, the study holds immense significance for diabetes management.

Shifting Paradigms: From Injections to Oral Diabetes Treatment

The landscape of diabetes treatment is poised for transformation. The researchers sought to address the challenges posed by conventional injection-based medications, such as exenatide and liraglutide, by exploring a novel avenue for effective and accessible oral treatment.

Unraveling Insulin Release Mechanisms: The Role of PK2 Molecule

Insulin release, a cornerstone of diabetes management, hinges on intricate biochemical processes. Central to this mechanism are GLP1R protein structures that facilitate insulin release triggered by the hormone GLP1. The researchers set out to harness this mechanism using the innovative PK2 molecule.

PK2 Emerges as a Promising Contender: Oral Administration Potential

Among the molecules screened, PK2 emerged as a frontrunner due to its effective binding with GLP1R and favorable solubility attributes. The researchers synthesized PK2 for further investigation, revealing its potential to seamlessly bind with GLP1R proteins and trigger insulin release.

Addressing Beta Cell Loss: A Dual Approach to Diabetes Treatment

The impact of PK2 extends beyond insulin release stimulation. This groundbreaking molecule showcases the ability to counteract and reverse beta cell loss, a crucial factor in insulin production. This dual mechanism holds the potential to revolutionize diabetes treatment for a wide range of patients.

Promising Results in Experimental Trials: Elevated Insulin Levels

In experimental trials involving mice with diabetes, oral administration of PK2 led to a remarkable six-fold increase in serum insulin levels compared to the control group. This discovery offers hope for the development of cost-effective and accessible oral diabetes medications.

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