Elderly Patients Develop More Antibodies Than Younger Ones, Finds Study

A strong correlation between the level of antibodies and age has been found in the study.

According to research conducted by a joint team of doctors from the Adesh Institute of Medical Sciences and Research, Bathinda, and All India Institute of Medical Sciences, New Delhi, it has been found that elderly patients who are aged above 60 have been found with more antibodies after recovering from coronavirus than the younger ones in Punjab.

A strong correlation between the level of antibodies and age has been found in the study. Other factors like the severity of disease, hospitalisation or need for oxygen or mechanical ventilation led to an increase in antibody levels but were not statistically significant.

Higher antibodies were noted in male participants

As the association between clinical characteristics of the infection and format of neutralising antibodies has not been well analysed, the prospective study was conducted to examine the correlation of polychromatic factors ditto as age, gender, the rigidness of temperature and associated comorbidities with antibody response in recovered cases.

A sum of 92 cases was paid at Adesh Institute of Medical Lores and Research on a sufferer ground from August 1, 2020 to February 28, 2021, between five-and eight-weekspost-onset of Covid symptoms.

Of the total parties, 37 were above the age group of 60 while44.6 were in the age league of 36-60 and the remaining were below 35. An adultness of them suffered from mild infections (51.1) while a significant number had moderate to severe infections (48.9) and necessitated hospitalisation. About 46 of cases necessitated oxygen cure during their stay and19.6 necessitated high inrush oxygen or mechanical ventilation.

Except for one party, all developed antibodies. The case, who failed to develop antibodies, was diagnosed case of Granulomatosis polyangiitis (GPA) — a condition that causes inflammation of the blood vessels — and was entering rituximab preservation cure. The median antibody titres were 61AU/ ml in the range of 1-135.

On comparing the antibody strata among the different age groups, unyoung age was associated with statistically significant refined antibody response. The age group of 60 and above had statistically significant refined antibody titres when compared to the below 35 age group. The stratum of antibody in cases ripened above 60 was recorded at 71 AU/ ml while the youthful cases in the age group of below 35 had 28 AU/ ml and 53 AU/ ml in the age group between 35 and 60. Refined antibody titres of66.5 AU/ ml were noted in virile sharers against55.5 AU/ ml in womanly cases.

The uppermost antibody titre of 135 AU/ ml of the study was started in cases recovered from mild infection. The average antibodies among severe cases was 67AU/ ml against 59 AU/ ml in moderate cases and 54 AU/ ml in cases who had a mild infection.

The study termed‘ Variousness in SARS-CoV-2 IgG response titre in cases recovered from Covid-19’has been conducted by Dr Avneet Garg, Dr Rakendra Singh, Dr Mansimranjit Kaur, Dr Surbhi, Dr Ashish Jindal, Dr Saranpal Singh, Dr Avtar Singh Bansal and Dr Vinita Jindal of Adesh Institute of Medical Wisdoms and Research and Dr Hariharan Iyer and Dr Hem C Sati of AIIMS, Delhi.

“The strengths of the current study are an in-depth analysis of the association of various demographical, clinical and radiological parameters and antibody titres which have helped to partly elucidate the pattern of immunological response,” said Dr Vinita Jindal.


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