Uttar Pradesh Government has approved Ivermectin to treat and prevent Covid-19 infection. Earlier, on August 4, in a high level meeting, called by the Director of heath department, experts had given their approval to use the medicine to prevent and treat Covid-19 among health workers and people who came into close contacts with the infected people.
They also recommended that the drug can be used to treat covid positive people. According to the order, issued by the state governments, the drug will not be used in pregnant women and children younger than 12 years.
Ivermectin is a medicine used to kill parasites. The drug is mainly used in creams and lotions for head lice. The medicine is also used in a tablet form to cure roundworm infection and second-line treatment for scabies and rosacea.
A set of findings by Monash University’s Biomedicine Discovery Institute (BDI) and the Peter Doherty Institute of Infection and Immunity (Doherty Institute), both in Australia, suggest that the drug can quickly prevent the replication of SARS-CoV-2, the virus that causes COVID-19.
- Ivermectin is an inhibitor of the COVID-19 causative virus (SARS-CoV-2) in vitro.
- A single treatment able to effect ~5000-fold reduction in virus at 48 h in cell culture.
- Ivermectin is FDA-approved for parasitic infections, and therefore has a potential for repurposing.
- Ivermectin is widely available, due to its inclusion on the WHO model list of essential medicines.
Originally identified as an inhibitor of interaction between the human immunodeficiency virus-1 (HIV-1) integrase protein (IN) and the importin (IMP) α/β1 heterodimer responsible for IN nuclear import , Ivermectin has since been confirmed to inhibit IN nuclear import and HIV-1 replication.
Other actions of ivermectin have been reported, but ivermectin has been shown to inhibit nuclear import of host and viral proteins, including simian virus SV40 large tumour antigen (T-ag) and dengue virus (DENV) non-structural protein 5. Importantly, it has been demonstrated to limit infection by RNA viruses such as DENV 1-4, West Nile Virus, Venezuelan equine encephalitis virus (VEEV) and influenza.