India’s Cipla Ltd has doubled production of Covid-19 medication remdesivir to help meet “unprecedented demand” as the country battles a massive second wave of infections, the drugmaker said on Tuesday.
On Sunday, the country banned the export of anti-viral drug remdesivir and its active pharmaceutical ingredients to deal with crippling shortages of the medication in many parts.
“We have scaled up the production of remdesivir by 2x from the last wave of the pandemic,” Cipla said in a statement. “Given the unprecedented demand for the drug, we have now further ramped up our capacities through our network.”
The company is working with authorities to restrict remdesivir supply just to hospitals and places with a high burden of severe Covid-19 cases, it added.
Cipla also warned that it was facing a shortage of tocilizumab, an arthritis drug developed by Roche that has been shown in trials to reduce the risk of death in patients with severe Covid-19.
Just two months ago, Cipla had projected falling demand for remdesivir in India as coronavirus infections were on a steady decline.
India has overtaken Brazil as the world’s second-worst coronavirus-hit country after the United States, having administered about 107 million vaccine doses among a population of 1.4 billion.
The World Health Organization in November issued a conditional recommendation against the use of remdesivir in hospitalized patients, saying there was no evidence that the drug improved survival and other outcomes. Still, many countries, including India, have continued its use.
Cipla, one of India’s oldest and largest drug manufacturers, has a deal to make and supply U.S.-based Gilead’s remdesivir in more than 100 countries. Several other Indian drug producers also have similar agreements.
“We expect intermittent supplies (of tocilizumab) as demand outstrips supply,” Cipla said.